![]() ![]() In vitro, they are selective for bacteria versus eukaryotic cells. ![]() While previous claims of universality relied on but a few proteins and on normal modes analyses (NMA) restricted to only torsional degrees of freedom and to the low-frequency range of 0 - 300 1/cm, our present study, including 135 proteins analyzed with a full atomic empirical potential (CHARMM22) and using the full complement of all atoms Cartesian degrees of freedom, finds that universality holds for all frequencies (up to 4000 1/cm), where seemingly idiosyncratic peaks and turns in the density of states are faithfully reproduced from one protein to the next.Īntimicrobial peptides (AMPs) are natural bactericidals and immunomodulators, and their action involves association to cell membranes and their perturbation. ![]() Here we show that the vibrational spectrum density of globular proteins is universal, that is, it closely follows one universal curve regardless of the fold, size and other details of the protein in question. The density of frequencies of the vibrational spectrum of proteins is the focus of much interest, as it is quite readily available experimentally, and a prerequisite for the theoretical computation of several physical properties of the proteins. ![]()
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